Erythropoietin is a hormone, created mainly in the kidneys, i beg your pardon stimulates the production and maintenance the red blood cells.

Alternative names for erythropoietin

Erythropoietin is typically referred to as EPO. It is also called haematopoietin or haemopoietin, yet these names space rarely used today.

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What is erythropoietin?

Erythropoietin (EPO) is a hormone that is developed predominantly by specialised cells dubbed interstitial cell in the kidney. When it is made, it acts upon red blood cell to protect them against destruction. At the exact same time that stimulates stem cell of the bone marrow to increase the manufacturing of red blood cells.


Erythropoeitin trial and error in sport. Blood sample gift tested because that the existence of the performance-enhancing hormone erythropoeitin.

Although the precise mechanisms that regulate the production of erythropoietin room poorly understood, it is well known that specialised cells in the kidney are qualified of detecting and responding to short levels the oxygen (hypoxaemia) through boosted production the erythropoietin. Once there is adequate oxygen in the blood circulation, the production of erythropoietin is reduced, yet when oxygen levels go down, the production of erythropoietin goes up. This is an adaptive mechanism since it facilitates the production of more red blood cell to transport an ext oxygen about the body, therefore raising oxygen level in the tissues. For example, when relocating in to a high altitude the air pressure drops and also this can reason hypoxia that stimulates rise in erythropoietin production. In short oxygen states, people risk occurring hypoxia - oxygen deprivation. Hypoxia can additionally occur when there is poor ventilation the the lung such as occurs in chronic lung disease, emphysema and in cardiovascular disease. The production of erythropoietin is lessened in certain conditions such together kidney failure, chronic illness like HIV/AIDS, and particular cancers and in chronic inflammatory illness like rheumatoid arthritis.

What happens if I have actually too lot erythropoietin?

Excess erythropoietin results from chronic exposure to low oxygen level or from rarely tumours that develop high levels of erythropoietin. It causes a problem known as polycythaemia which way high red blood cell count. In countless people, polycythaemia does not cause any symptoms. However, there space some general and non-specific symptoms consisting of weakness, fatigue, headache, itching, joint pain and dizziness.

What happens if I have too small erythropoietin?

If you have actually too small erythropoietin, which is usually led to by chronic kidney disease, there will certainly be under red blood cells and you will have anaemia. Erythropoietin has been made synthetically for the therapy of anaemia that outcomes from chronic kidney failure. That is likewise given come patients through some rarer varieties of cancer.Some expert athletes have actually used this type of erythropoietin (known as blood doping) to enhance their performance, specifically to rise endurance. Artificially increasing your erythropoietin levels produces much more haemoglobin and also red blood cells and therefore enhances the amount of oxygen that can be yielded to tissues, specifically muscles. This deserve to improve power capacity, back this form of doping practice is banned by most expert sport committees.

Can us measure erythropoietin in the blood?

Yes, erythropoietin hormone levels have the right to be measured in the blood. The test is done with a simple blood test, best a morning sample collection. A needle is provided for illustration blood native a vein on your arm. You don’t need any kind of special preparations before a blood test, however you need to let your medical care provider recognize if you space taking any kind of medications, vitamin additional or any type of illicit drugs or herbs.

The test Results

The test results may vary based on your age, sex, wellness status, and even the technique used because that the test. Your health care provider will talk about your results with you.

Too small erythropoietin could be because of anaemia (low red blood cells), specifically anaemia as result of kidney disease. Raised levels of erythropoietin can be because of a condition called polycythaemia (too numerous red blood cells) or it might be proof of a kidney tumour.

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EPO doping in Athletes

Raised levels of Erythropoietin in athletes indicate erythropoietin abuse (doping). EPO doping can an increase the number of red blood cells and there by increased ease of access of oxygen to the muscles. This can aid the athlete with enhanced performance capability and endurance. Blood doping is illegal specifically in experienced sports. Experienced athletes are asked to take it this test to find out if they space violating the anti-doping law.